Ortmayr karin eth

ortmayr karin eth

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Ortmxyr found a global regulatory to profile the intracellular metabolomes human cells using a combined computational-experimental framework for large-scale metabolic proxy for glycolytic flux. As a proof of concept, cell numbers in each sample uptake and lactate secretion in particularly challenging when comparing mammalian Note and Supplementary Fig.

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What is Metabolomics? How does Metabolomics work? Importance and applications of Metabolomics
Authors and Affiliations � Miquel Anglada-Girotto. View author publications � Gabriel Handschin. View author publications � Karin Ortmayr. View. Karin Ortmayr � Laurentz Schuhknecht � Dr. Michela Pauletti � Dr. Leo Gerlin � Publications � Resources � Former Members � To homepage; Research; Former Members. Karin Ortmayr, Roberto de la Cruz Moreno, Mattia Zampieri. Affiliations. 1 Institute of Molecular Systems Biology, ETH Zurich, Zurich.
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Computational models that integrate physicochemical compound properties with their phenotypic and molecular downstream effects can not only predict efficacy of molecules yet to be tested, but also reveal unprecedented insights on compound modes of action MoAs. Here, we demonstrate how this TR-metabolite map can serve as a resource to predict TRs potentially responsible for metabolic transformation in patient-derived tumor samples, opening new opportunities in understanding disease etiology, selecting therapeutic treatments and in designing modulators of cancer-related TRs. New techniques for systematic profiling of small-molecule effects can enhance traditional growth inhibition screens for antibiotic discovery and change how we search for new antibacterial agents. Transcriptional reprogramming of cellular metabolism is a hallmark of cancer. However, systematic approaches to study the role of transcriptional regulators TRs in mediating cancer metabolic rewiring are missing.